Israeli Prime Minister Benjamin Netanyahu warned on Tuesday night that Iran had made a "big mistake" by launching missiles at Israel. During a security cabinet meeting in Jerusalem, Netanyahu vowed that Iran would "pay for it," according to a report by The Times of Israel.

The missile strike, which targeted Israel earlier in the evening, was unsuccessful, Netanyahu stated, crediting Israel's advanced air defense system for thwarting the attack. He also expressed gratitude to the United States for its support.

On Tuesday, Iran launched over 400 missiles towards Israel, forcing millions of Israelis to seek shelter as sirens blared across the country. The Israeli Defence Forces (IDF) later announced that, after a situational assessment, civilians could leave their shelters but were advised to remain cautious and follow instructions from the Home Front Command.

In an official statement following the missile strike, Iran claimed responsibility, saying the attack was in retaliation for the deaths of Ismail Haniyeh, Sayyed Hassan Nasrallah, and Martyr Nilforooshan. Iran's mission to the United Nations called the attack a "legal and legitimate response" to what it described as terrorist actions by Israel.

Iranian President Masoud Pezeshkian also issued a warning to Netanyahu, stating that while Iran is not belligerent, it would respond firmly to any threat. "This is just a glimpse of our power," Pezeshkian said, cautioning Israel against further conflict with Iran.

Meanwhile, Iran’s Supreme Leader Ayatollah Ali Khamenei was reportedly moved to a secure location, according to a senior Iranian official cited by Reuters. The missile strike marks a significant escalation in tensions between the two countries, prompting a strong response from the United States.

US President Joe Biden ordered the US military to assist in Israel's defense, authorizing the interception of Iranian missiles. The White House reaffirmed its commitment to protecting its allies and warned Iran of "severe consequences" if the situation worsens.

In response to the growing conflict, US Secretary of Defence Lloyd Austin spoke with Israeli Defence Minister Yoav Gallant, reinforcing US support for Israel and highlighting the increased readiness of US forces in the region.

The missile barrage from Iran follows Israel's military operations against Hezbollah in Lebanon earlier on Tuesday. The Israeli military confirmed that its ground forces had crossed into Lebanon as part of a targeted operation against Hezbollah positions, further intensifying the conflict after a week of heavy airstrikes.

As tensions rise, Israel has imposed stricter restrictions on civilian gatherings in Jerusalem and Tel Aviv, signaling preparations for possible retaliation from Hezbollah or Iran. Israeli forces continue to carry out limited raids along the border with Lebanon, targeting Hezbollah strongholds.